The Landesliga Mittelrhein is the second highest amateur football league in the region of Middle Rhine which is part of the state of North Rhine-Westphalia and since 2012 the sixth tier of the German football league system.

In the German football league system, the Landesliga was first established as second-rate below the Oberliga West and was later slipped five times down to the seventh level by the introduction of the aforementioned higher leagues.

The Landesliga Mittelrhein consists of eastern and western groups of 16 clubs each.

The exact number of teams is carried out every year on a geographical basis.

The champions of each group are promoted to the Oberliga Mittelrhein, provided they are not reserve teams of senior clubs or are financially sound.