As a politician, he was the leader and vice president of the moderate Liberal Party and was granted the portfolio of Minister of Labour and Social Affairs in the Habyarimana transitional government put in place after the Arusha Accords.

[2] On February 17, 1994, UNAMIR commander Roméo Dallaire received information of a plot to assassinate Ndasingwa and Joseph Kavaruganda, both prominent political moderates.

As an outspoken and well-known public figure, Ndasingwa was the frequent target of attacks on propaganda radio station RTLM.

[5] On April 7, 1994 , Ndasingwa and his Canadian wife, Hélène Pinski, both graduates of the Université de Montréal, were abducted from their house along with their two children, Malaika (age 17) and Patrick (age 15), and Ndasingwa's mother by the government's Presidential Guard, despite being under UNAMIR protection.

"[6][5][1] One of his sisters, Louise Mushikiwabo, became much later (December 2009) Minister of Foreign Affairs and Cooperation in Paul Kagame's government, and, then (October, 2018), Secretary General of the Organisation internationale de la Francophonie.