[4] ISSC's subsidiary Land's End Airport Limited operates the airport, and another subsidiary, Isles of Scilly Skybus, operates a regular passenger service to St Mary's in the Isles of Scilly as well as scenic flights around west Penwith.

The airport has a CAA Private Use Aerodrome Licence (Number P568) that allows flights for the public transport of passengers or for flying instruction for daytime use only as authorised by the licensee.

[6] In 1984, Isles of Scilly Skybus started operations at the airport, initially freight and charter, then scheduled services from April 1987,[9] flying Islanders and de Havilland Canada DHC-6 Twin Otters.

[6] Skybus became the sole remaining air link for the Isles of Scilly from October 2012, when the helicopter service from Penzance ended.

During the winters of 2012/13 and 2013/14 the airport closed for long periods when the runways became waterlogged, and flights were temporarily moved from Land's End to Newquay.

[10] In May 2013, ISSC and the Council of the Isles of Scilly submitted a bid for finance from the European Regional Development Fund for runway resurfacing at Land's End, together with various improvements at St Mary's.