Landscape with Polyphemus (Paysage avec Polyphème) is a 1649 oil painting by French artist Nicolas Poussin.

The painting refers to a Spanish literary work La Fábula de Polifemo y Galatea and Ovid's Metamorphoses.

On green fields behind them people listen to music played on a flute by the Cyclops Polyphemus, who appears to be blended into rocky mountains in the background.

In 1722 the painting was acquired for the Spanish king Philip V by Andrea Procaccini, a student of Carlo Maratta.

[3] Later, it was part of the collection of a French marquess who sold it in 1772 to a Russian prince, with the help of Denis Diderot, in order to pay a gambling debt.