Monsignor Joseph Schade wanted to create the school with the purpose of offering competitive Catholic education to families in the surrounding area with the closest school at the time being located in The City of Philadelphia, and was aided in his efforts with help from the Sisters of St. Francis of Assisi of Philadelphia[2] In September 1960, the present facility opened at 7th Street and Lansdale Avenue on a property that consisted of approximately 79 acres (32 ha) of land, and the first class graduated from there in 1961.

Although the sports teams had long been referred to as Lansdale Catholic, it was with the opening of the new facility that the name of the school was "officially" changed to Lansdale Catholic High School.

It was made possible primarily through the support of the Business Leaders Organized for Catholic Schools.

In more recent years, other improvements were added including another on-site parking facility, baseball field, window replacements, air-conditioning in the gymnasium, reconditioning of the football and lacrosse fields.

On January 28, 2008, the Roman Catholic Archdiocese of Philadelphia announced that the school would move following the 2012 graduation pending funding.