It was originally built in 1902 by the Reading Company, opening on February 7, 1903; a freight house was added in 1909.

Additionally, the station served commuter trains on the Reading's branch to Bethlehem until service was ended in 1981.

[9] Lansdale station is near the SEPTA's 25 Hz Traction Power System plant, originally built by the RDG.

The station interior was formerly home to an internet café, and Italian deli called "A Little Something Nice".

Proposals for service restoration to Quakertown have been floated around since the late 1990s, but nothing has gone past the discussion phase.