Built in 1870,[1] it was the residence of Zachary Lansdowne, who was a pioneer in the development of the U.S. Navy's airship program and commanded the airship Shenandoah.

A native of Greenville, Lansdowne attended the United States Naval Academy upon graduating from Greenville High School;[2] as Shenandoah's skipper, he was killed in its crash on September 3, 1925.

It is a simple two-story rectangular frame structure,[2] topped with a shingled roof and supported by a foundation of limestone.

[4] In 1979, the Lansdowne House was listed on the National Register of Historic Places.

It qualified to be added to the Register because of its connection to Zachary Lansdowne.