Largentière (French pronunciation: [laʁʒɑ̃tjɛʁ] ⓘ; Occitan: L'Argentièira) is a subprefecture and commune of the Ardèche department in the Auvergne-Rhône-Alpes region in Southern France.

It is located in the narrow valley of the Ligne, approximately 10 km (6.2 mi) southwest of Aubenas.

Its name, adopted in the 13th century in place of its more ancient name Segualeriae (Ségualières), refers to the silver mines in the area between the 10th and 15th centuries, when the silver-bearing lead ores in intrusive veins in the Largentières sandstone[3] were exploited under the authority of the Counts of Toulouse and the Bishops of Viviers, whose title Barons de Largentière was linked to the bishopric.

Its only railroad station was demolished in 1982, leaving the town accessible only by road.

Besides its twelfth- to fifteenth-century château, the town conserves its thirteenth-century church, Nôtre-Dame-des-Pommiers,[6] its Renaissance hôtel de ville, its palais de justice, and the Tour Argentière that collected the mines' produce for guarded transport.