After two years in San Diego, he was then traded to the Miami Dolphins where he played for the rest of his career, establishing himself as one of the best guards in the NFL.

He was the starting right guard of a dominant Dolphins offensive line which included Hall of Fame center Jim Langer and left guard Bob Kuechenberg, that was instrumental in the Dolphins winning Super Bowl VII during their perfect season in 1972, and Super Bowl VIII the following year.

[2] He attended Booker T. Washington Senior High School in Miami, where he played football as a two-way lineman.

He was a team captain, and a three-time All-Southern Intercollegiate Athletic Conference (SIAC) selection.

[9] After playing for San Diego in 1967 and 1968, coach Sid Gillman grew frustrated with Little's not controlling his weight.

[6] Little was a key contributor to the success of the Dolphins' punishing running attack of the early and mid-1970s, which featured Larry Csonka, Mercury Morris, and Jim Kiick.

[6] Little played under offensive line coach Monte Clark, whom Little acknowledged at his Hall of Fame induction.

[6][11] He was named the National Football League Players Association's AFC Offensive Lineman of the Year three times (1970-1972).

[18] He also served as head football coach of his alma mater, from 1983 to 1991, winning Mid-Eastern Athletic Conference championships in 1984 and 1988.

At least four of his NCCU players, Shawn Gibbs, Adrian Jones, Trei Oliver, and Dawson Odums went on to become college football coaches.

[4][19] In addition, Little served as head coach of the Ohio Glory of the World League of American Football (which eventually became the now-defunct NFL Europe), for one year.

[10] In 1993, Little was inducted into the Pro Football Hall of Fame, with the NFL's all-time winning coach Don Shula[20] as his presenter.