[1] Las Vegas Boulevard serves as the Valley's east/west address demarcation boundary line south of the Strat onwards.

As the road enters the city of North Las Vegas, it passes through some of the older commercial areas in the region.

Further south is a stretch of road that has many of the older motels, bars and wedding chapels that were among the high points of the old Vegas before the era of the megaresorts.

This is the section of the road most people are familiar with; it is home to casino megaresorts with their world-famous lights, huge video signs, and other attractions.

Just past the end of "The Strip", the road passes the Welcome to Fabulous Las Vegas sign (located in the median) as it abuts the western edge of the Harry Reid International Airport property.

South of Jean, the road ceases to be a major artery for a stretch of several miles before resuming just north of Primm, where it runs alongside two of the resort's hotels and shopping mall; just short of the Nevada/California state line, the road changes its name to Lotto Store Road (appropriately serving a convenience store across the state line whose only purpose is to sell California Lottery tickets to Nevadans), then loops around the shopping mall as Fashion Outlet Way before ending at Primm Valley Boulevard.

RTC Transit Route(s) 113 (and the MAX, before February 2016, when it was decommissioned) serves the road from Downtown Las Vegas north to Nellis Air Force Base, The Deuce serves the Road from Downtown Las Vegas south to Warm Springs and then to the South Strip Transfer Terminal (SSTT)).

Just north of Jean[2] is the place where the last spike on the San Pedro, Los Angeles, and Salt Lake Railroad line was driven.