[1] Lascăr Catargiu rose to the office of prefect of police in Iași under the rule of the Moldavian Prince Grigore Ghica (1849–1856).

Lascăr Catargiu consequently took part in the so-called monstrous coalition that toppled Cuza, and, on the accession of Domnitor Carol I in May 1866, became President of the Council of Ministers but, finding himself unable to cooperate with his Liberal colleagues, Ion Brătianu and C. A. Rosetti, he resigned in July.

After eight more ministerial changes, culminating in the anti-dynastic agitation of 1870–1871 (provoked by the Liberals in the context of the Franco-Prussian War; see also Republic of Ploiești), Catargiu formed, for the first time in Romanian history, a stable Conservative cabinet, which lasted until 1876.

His policy, which averted political violence and revived the popularity of the crown, was regarded as unpatriotic and reactionary by the Liberals, who resumed office in 1876; and a proposal to impeach the whole Catargiu cabinet was only withdrawn in 1878.

In the Ion Emanuel Florescu cabinet of March 1891 he occupied the same position, and in December he again became president of the Council, retaining office until 1895.