Meyers's first guests were fellow SNL alum and Weekend Update co-anchor Amy Poehler, then-Vice President of the United States Joe Biden, and musical act A Great Big World.

[10] On May 13, 2024, NBC once again renewed Meyers's contract to remain as host through 2028,[11] however due to a cut in the show's budget, the 8G Band would be laid off.

After one last on-air appearance on August 22, 2024, the band will continue to provide pre-recorded music for show openings, segment intros/outros, and guest entries.

[12][13][14] Late Night with Seth Meyers originates from NBC Studio 8G in the Comcast Building at 30 Rockefeller Center in New York City.

[17] Architectural Digest writes that the stage "strikes an Art Deco tone, with its illuminated proscenium arch reminiscent of the Chrysler Building's iconic crown.

Just before Marnie Stern took over for Fred Armisen as guitarist in 2015, the role of drummer was held by Kimberly Thompson, who performed trumpets, backing vocals and melodicas since the premiere of Late Night on February 24, 2014.

[22] The show opens with Ron McClary proclaiming "From 30 Rockefeller Plaza in New York, it's Late Night with Seth Meyers!"

Meyers performs a monologue from his desk based around recent news, punctuating jokes with on-screen images and video.

After the first commercial, one of various recurring segments appears, followed by the first of the episode's guests, which usually include celebrities and actors, literary figures, people in fashion, artists, athletes, and politicians.

This first occurred following the series finale of Parks and Recreation, an NBC sitcom starring Meyers's former co-anchor and close friend Amy Poehler.

[25] This occurred again with the cast of the then-upcoming film Sisters (which starred Poehler), although the episode featured a short desk segment between the monologue and interviews.

[26] An annual holiday tradition since the show's debut year has been an episode broadcast on Thanksgiving night in which the only guests are Meyers's parents, Hilary and Larry, and his younger brother Josh.

"[30] In July 2016, it was announced that the show would produce two live episodes following the final nights of the Republican and Democratic National Conventions.

Will Forte, Mandy Moore, and David Ortiz were the guests, with a special appearance by Weekend Update co-anchor Colin Jost.

Club gave a B grade: The show begins with, "essentially, a carbon copy of Meyers's Weekend Update / 'what's in the news' jokes [...] Meyers will settle in to the formulaic parts of this job quickly enough—he's a pro, and it shows... "[99] A month later, Jeff Jensen of Entertainment Weekly gave the program a B+ and wrote, "In his first week, the very smart, very smiley former Saturday Night Live head writer gave stiff monologue, which was basically his Weekend Update newsreader shtick, delivered in his shouty, wiseassy, talk-to-the-camera manner, but standing up; he improved the more he connected with the studio audience.

Meyers seems capable of creating chemistry and having quality chats with anyone, from riding the wild waves of Kanye West to spinning a funny anecdote with pal Brad Paisley about accidentally stealing a Porsche.

In 2015, David Sims of The Atlantic wrote that the program "quietly [became] a heavy hitter, mixing a solid monologue with great scripted and semi-improvised bits from its writers.

[27] The 2016 election cycle allowed the show to further increase its focus on politics, satirizing the daily news both in the monologue and longform "A Closer Look" segments.

Meyers's transition from broad appeal comedy to his personal views has been critically praised by some outlets, saying that the show has been able to find its own footing more in these political pieces.

[89] Conversely, Jonny Coleman of LA Weekly called Meyers a "purveyor of toxic fluff" who has "demonstrated zero political efficacy.

"[101] Dave Itzkoff of The New York Times praised "A Closer Look" and Meyers for embracing a more political style, noting "This approach has helped 'Late Night', which was drawing more than 1.6 million viewers at the end of last year, stand out in a crowded field of competitors, and has earned Mr. Meyers praise from viewers, critics and his fellow hosts.