[3] Eupatorium serotinum ranges throughout most of the eastern United States, found in every coastal state from Massachusetts to Texas and inland as far as Minnesota and Nebraska.

The leaf arrangement is alternate, although it can be opposite at some upper nodes.

Unlike wind-pollinated plants in this genus, E. serotinum is pollinated by insects.

[7] Eupatorium serotinum provides late-season nectar for Monarch Butterflies.

[8] There is also evidence that pyrrolizidine alkaloids produced by Eupatorium serotinum are beneficial to Monarchs.