[1][2] It passes across the axillary artery and vein,[3] pierces the clavipectoral (coracoclavicular) fascia, and enters the deep surface of the pectoralis major to innervate it.

It arises either from the lateral cord or directly from the anterior divisions of the upper and middle trunks of the brachial plexus.

An ultrasound-guided pectoral nerve block can also be performed preventively before the operation by an anesthesiologist, experienced in regional anesthesia.

Spasms of the pectoralis major muscle and resulting severe pain (acute or chronic) may be reduced by pectoral nerve block or neuromuscular relaxation.

“The skin projection point of the neurovascular bundle (NVB) represents the denervation point (DP).” The NVB (thoracoacromial artery and vein, plus the lateral pectoral nerve) may be the guide for local anesthetic applications in order to achieve pectoral muscle denervation.