Latest Greatest Straitest Hits is the fifth compilation album by American country music artist George Strait.

The set contains two newly recorded tracks.

Although not a single, "Murder on Music Row" (a duet with Alan Jackson) also charted in the Top 40 from unsolicited airplay.

Another notable omission is "I Just Want to Dance with You", a #1 hit from 1998.

In March 2003 the album was certified Double Platinum by the RIAA.