[1][2] Alexandria, the ancient great port of Egypt and a first-rank Mediterranean metropolis in the Hellenistic world, was an influential early Christian diocese.
[3] Thus, while in 1215, during the pontificate of Pope Innocent III, there were Latin patriarchs, rivaling or replacing the Greek ones in the formerly Crusader held cities of Antioch, Constantinople, and Jerusalem, Greek Patriarch Mark III of Alexandria was invited and sent representatives to participate in the Fourth Lateran Council.
His patriarchal cathedral in Rome was the papal Basilica of Saint Paul Outside the Walls.
Many incumbents would hold residential (arch)episcopal posts of various ranks in Catholic countries, and even (earlier and/or later) other Titular Latin patriarchates (Jerusalem, Constantinople).
The titular Latin Patriarchate of Alexandria was left vacant in 1954 and suppressed in January 1964 along with those of Antioch and Constantinople.