[1] Guggenbühl was born in New York City, to a family of Swiss immigrants; her father, a butcher and baker, died by 1920.
[2] She became a regular-rank faculty member at Hunter College in 1932 and retired from there as an associate professor in 1972.
[1] She died on a round-the-world cruise, shortly after leaving Hong Kong, after being overcome with grief at the recent death of her brother.
[1] Although not active in research mathematics after her doctorate, Guggenbühl represented Hunter College at many offerings of the International Congress of Mathematicians.
She also published several works on the history of mathematics, including biographies of Henri Brocard and Karl Wilhelm Feuerbach, on elementary geometry including triangle geometry, and on the Rhind mathematical papyrus.