From 2013 until its 2024 closure,[1] she was President of the Center for Modern Italian Art in New York City.
[3] Mattioli's childhood was unconventional and most of her younger years were spent with nannies and, rather than friends, artists, critics and intellectuals her parents would see regularly including modernist Mario Sironi, art historian Fernanda Wittgens, Giorgio Morandi, Fortunato Depero, Giacomo Manzù and Marino Marini .
Her father had other ideas and had Laura begin training in art history with a family friend.
[4] From 1975 to 1981, she taught at the Università degli studi di Milano and at the Accademia Carrara from 1992 to 1999.
In 1999, she edited Foppa e la Cappella Portinari, Milan, which includes her essay, "I restauri: interventi e interpretazioni (The restorations, interventions and interpretations)."