She was named the winner on March 25, 2007, which meant she would perform the lead character of Sandy opposite Max Crumm, who won the role of "Danny".

Osnes and Crumm played their final performances as Sandy and Danny on July 20, 2008, and they were succeeded by Ashley Spencer and Derek Keeling, two of the runners-up of Grease: You're the One that I Want!.

[6] She then played Elizabeth (Lizzy) Bennet for the concert version of the new Broadway-aimed musical Pride & Prejudice that was presented October 21, 2008, at the Eastman Theatre in Rochester, New York.

On January 11, 2009, she took part in the Rock Tenor Showcase, a showcase of a new concert experience that melds classical and Broadway music with rock-n-roll songs, at the Florence Gould Hall in Manhattan,[8] and then sang at Dreamlight Theatre Company's "Bright Lights" concert series on the evening of January 26 entitled A Night with The Ladies.

[9] In March 2009, Osnes took over the role of Ensign Nellie Forbush in the Lincoln Center Theater Broadway revival of South Pacific.

Osnes then played Hope Harcourt in the Broadway revival of Anything Goes, which began previews on March 10, 2011, and officially opened on April 7, 2011, starring Sutton Foster and Joel Grey.

However, despite the critics' distaste for the production, Osnes received rave reviews for her performance as well as her first Tony Award nomination for Best Leading Actress in a Musical.

[20] Osnes next performed at the 2011 Kennedy Center Honors in a tribute to Barbara Cook alongside Sutton Foster, Rebecca Luker, Kelli O'Hara, Patti LuPone, Glenn Close and Audra McDonald.

Also featured were Tony Goldwyn as Captain von Trapp, Brooke Shields as Elsa Schraeder and Patrick Page as Max Detweiler.

[31] Osnes starred as Julie Jordan in the Lyric Opera of Chicago's production of Carousel, alongside Steven Pasquale, in spring 2015.

Following the closing of Bandstand, Osnes has performed frequently in the Broadway Princess Party show that premiered at Feinstein's/54 Below, which she also hosts and co-developed with music director Benjamin Rauhala.

She also performs in this show on the road consistently with fellow Broadway actresses Susan Egan (Beauty and the Beast, Hercules) and Courtney Reed (Aladdin).

[38][39] In 2011 Osnes was cast in the pilot for HBO's The Miraculous Year, starring Lee Pace, Susan Sarandon, Patti LuPone, Eddie Redmayne and Norbert Leo Butz;[40] the show was not picked up by the network.

[40][42] In 2015, she was the guest artist for the annual Pioneer Day Concert of the Tabernacle Choir at Temple Square, Music for a Summer Evening, broadcast on BYUtv.