In 2012, she starred in the film For a Good Time, Call..., which she also co-wrote and produced, and in 2018 made her directorial debut with Like Father.

[4][5][6] Miller attended the Lois Cowles Harrison Center for the Visual and Performing Arts for High School.

It was there that she met Katie Anne Naylon, the college roommate with whom Miller would later co-write For a Good Time, Call..., based on their personal experiences.

[7] At the beginning of her career, Miller performed supporting roles in several of Seth Rogen's films, including Superbad, Zack and Miri Make a Porno, Observe and Report, and 50/50.

[13] In 2012, Miller and Rogen founded the non-profit organization Hilarity for Charity to raise awareness and fund research towards Alzheimer's disease.