[3][4] Vanthoor also became the youngest driver ever in the history of the Macau Grand Prix and he finished in sixth position.

He also drove in Brazil for the 1st round of the Stock Car Brasil together with Valdeno Brito for Shell Racing at Goiania.

On 3 October, during the event at Misano for the Blancpain Sprint Series, he was involved in a major crash which led to a serious injury.

During the 2018 season Vanthoor also completed the Porsche Le Mans line-up for the #92 car together with Kévin Estre and Michael Christensen in the iconic “pink pig” livery.

After taking the lead early on the team went on to win the GTE Pro class at the 2018 Le Mans 24 Hours.

The following season Vanthoor won the WeatherTech SportsCar Championship in the GTLM class for Porsche together with Earl Bamber.

However, Vanthoor was kept as a Porsche factory driver and loaned out to customer team Pfaff Motorsports for the 2021 IMSA season.

Vanthoor also won the 24 Hours of Spa a second time in 2020 driving a Porsche 911 GT3 R entered by Rowe Racing.

In 2022 Vanthoor participated in the Deutsche Tourenwagen Masters for SSR Performance, driving a Porsche 911 GT3 R. For the 2023 season, Vanthoor moved into the Hypercar class of the FIA World Endurance Championship, partnering Kévin Estre and André Lotterer at the Porsche Penske Motorsport works team.

[11] Vanthoor and his teammates finished sixth in the standings, beating the sister car by ten points.

In 2025, Vanthoor won the 2025 24 Hours of Daytona with Felipe Nasr and Nick Tandy after starting the endurance race in 3rd.