When a large number of players had to leave Péruwelz after the 2008–09 season, Eendracht Aalst took advantage of the situation in the summer of 2009 and signed Depoitre alongside Damien Galucci and Olivier De Castro.

In the 2011–12 season Depoitre was followed by, among other clubs, AA Gent, Lierse SK, Oud-Heverlee Leuven, Beerschot AC, N.E.C., Heerenveen, Willem II and Roda JC.

Afterwards, his transfer turned out to be a part of a share transaction between Yves Lejaeghere, the then-president of Ostend, and Patrick Decuyper, the then-general manager of Zulte Waregem.

[citation needed] After Depoitre decided not to extend his contract with Oostende, it was announced that he would play for KAA Gent during the 2014–2015 season.

[12] On 10 October 2015, he made his senior debut for the national team in a 4–1 win in a UEFA Euro 2016 qualification match against Andorra.