He is known for his singles "GODFLOW", "Break the Walls" and "Man on a Mission" along with his songs "Drug of Choice", "Open Heart Surgery", "Underdog", "MTBK" and "Decapitation Chamber" featuring Nusrat Fateh Ali Khan, Bizarre, Royce da 5'9", Bohemia and Ghostface Killah respectively.

He told in an interview to The Source magazine that after 9/11 he felt that his chances of becoming a rapper were finished and that his stage name metaphors the biblical character that was resurrected from the dead.

Another music video of the single "Drug of Choice" from his mixtape Lazarus Story (2010) received worldwide coverage and also gained over a million views on YouTube.

[7][8] In 2013, Lazarus signed to Russell Simmons' YouTube multi-channel network All Def Digital and in 2014 he released the single "Open Heart Surgery" featuring D12's rapper Bizarre.

[21][22] In January 2017, Lazarus and Punjabi rapper Bohemia released their collaborative track "MTBK" ("Mundian To Bach Ke") featuring Deep Jandu and Shaxe Oriah.

[25] In December 2017, Lazarus celebrated the 10 year anniversary of his highly received 2007 track "GODFLOW" by releasing a music video for it.

[26] In March 2018, Lazarus was featured on the track "Raindrops" alongside Royce da 5'9", Obie Trice and Swifty McVay of D12 on the mixtape No Parachute.

The song was produced by Rebel of KhanArtists and introduced by Chuck D.[29][30] Lazarus toured with Ghostface Killah in Canada to perform the single.

The song was also awarded a plaque for having reached 5 million downloads off the Wu-Invasion Mixtape it was featured on hosted by Ghostface Killah and DJ Symphony.

[31] In August 2018, Lazarus performed alongside Swifty McVay of D12 and Obie Trice in Pontiac, Michigan to promote the soundtrack of Devil's Night: Dawn of the Nain Rouge.

[33] In October 2018, Lazarus released the music video of "Decapitation Chamber" with Ghostface Killah and then toured with him in Vancouver, Canada and San Francisco, California.

[45] In April 2020, Lazarus was interviewed by DJ Vlad on VladTV to discuss his experiences as a physician on the front lines of combating COVID-19 at his hospital in Las Vegas.

[46] In May 2020, he was interviewed by DJ Vlad again and also appeared on the song "Fit In" by 80 Empire which also featured Fred the Godson & Bishop Lamont.

[49] Lazarus then released his full Urdu track "Qatal" and "Bande Kharab" featuring 10-year-old Pakistani rapper Kaky Thou$and on Laz Army Records.

In August 2021, Lazarus dropped the theme song for WWE wrestler Jinder Mahal for his SummerSlam 2021 PPV match up.