After serving the Spanish Empire as a soldier, he participated in the 1820 October 9 Revolution which led to the independence of Guayaquil from Spain.
He also held several minor political positions in various localities, until he served as a deputy to the Congress of Gran Colombia.
On 27 February he initiated the "Thirty Days Campaign" in the Gran Colombia–Peru War which culminated in the victory of the Battle of Tarqui.
Together with General José Antonio Páez he fought against the Revolution of the Reforms of 1835, and conquered the Castillo San Felipe in Puerto Cabello, which put an end to the revolt on 1 March 1836.
He participated in the March 1858 Revolution and when the Federal War broke out, General Febres Cordero assumed command of the Conservative army that was first defeated in the Battle of Santa Inés (December 1859).