It was an important port during the Iron Age at a time when lagoons connected to the Mediterranean Sea covered the adjoining low-lying land.

A cache of 3rd-century-BC weapons has been found which included swords, shields, spears and knives, along with about thirty human skulls which showed signs that the bodies had been decapitated.

By the time of the French Revolution, there were only a few traces of the medieval castle which nevertheless is remembered as an important item in the history of the village.

[5] Le Cailar is located at the confluence of the Rivers Vistre and Rhôny, about 26 km (16 mi) southwest of Nîmes on the edge of the Languedoc coastal plain.

The village is also receptive to modern art with Figuration Libre exhibitions encouraged by painters including François Boisrond.