Le Mée-sur-Seine (French pronunciation: [lə me syʁ sɛn] ⓘ, literally Le Mée on Seine) is a commune in the Seine-et-Marne department in the Île-de-France region in north-central France, next to Melun.

It is located in the south-eastern suburbs of Paris 41.1 km (25.5 mi) from the center.

The town is located on the right side of the Seine on a limestone plateau.

The town grew quickly after World War II, and it is now divided in four districts: Le Mée Village, Plein Ciel, Croix Blanche, Les Courtilleraies.

Le Mée-sur-Seine is served by the station of the same name on Paris's RER line , approximately 45 minutes from the centre of Paris.