Le Puy (French pronunciation: [lə pɥi]; Gascon: Lo Puèi) is a commune in the Gironde department in Nouvelle-Aquitaine in southwestern France.

The economy is agricultural, with wheat, sunflowers and soya being grown in recent years to complement the more traditional plums and tobacco.

The town lies in the Dropt basin which covers nearly 1,500 km2 (580 sq mi) in Guyenne, from Quercy to the Bordelais.

The alluvial plain of the Dropt is characterized by boulbène (a soil composed of clay and sand) terraces, rising to foothills of molasse (chalky sandstone sedimentary deposits) with a few hillocks or the edges of chalky plateaus.

The Sisters of St. Joseph were founded in Le Puy in 1650 by Jesuit Priest Jean Pierre Medaille.