She also starred in the Broadway productions POTUS: Or, Behind Every Great Dumbass Are Seven Women Trying to Keep Him Alive in 2022 and the 2000 revival of The Rocky Horror Show.

[3] She attended kindergarten through eighth grade at St. Mary's Elementary School in Belleville[6] and has referenced her Catholic upbringing in her performances.

[9] "Ten Percent Revue" was performed in Boston, San Francisco, Provincetown, Philadelphia, and Atlanta.

[10] From 1987 to 1989, DeLaria starred in "Dos Lesbos", a musical comedy about two lesbians dealing with the issues of living together.

DeLaria appeared as Jane in the 1998 Off Broadway production of Paul Rudnick's The Most Fabulous Story Ever Told, "a gay retelling of the Bible.

"[17] Entertainment Weekly said "a star is born with Lea DeLaria" of her "showstopping" performance as Hildy Esterhazy in the 1998 Broadway revival of On the Town.

[18][19][20] DeLaria subsequently played Eddie and Dr. Scott in the 2000 Broadway revival of The Rocky Horror Show, and can be heard on the cast recording.

DeLaria integrates musical performance into her stand-up comedy, focusing on traditional and modern be-bop jazz.

She also frequently collaborates with comedian Maggie Cassella, most notably on an annual Christmas cabaret show in Toronto, Ontario which also sometimes tours to several other North American cities.

[26][27][28] In December 2014, DeLaria voiced EJ Randell, the lesbian mother of Jeff in the Cartoon Network animated series Clarence.

[31][32][33][better source needed] In 2022, DeLaria returned to Broadway in the comic play POTUS: Or, Behind Every Great Dumbass Are Seven Women Trying to Keep Him Alive where she received positive acclaim from critics.

[35] In January 2015, DeLaria became engaged to fashion editor Chelsea Fairless after two and a half years of dating.