In 2022, Jeffries was cast as Annabeth Chase in the television adaptation of Rick Riordan's fantasy novel series, Percy Jackson & the Olympians.

[3] Prior to her acting debut, Jeffries worked as a model for children's products for Carol's Daughter.

Immediately following the casting announcement, Jeffries received harassment online because she was African-American, while her character, Annabeth Chase, was portrayed as white in the book series the show was based on.

[4][8][9] Alexandra Daddario, the actress who played Annabeth in the two movie adaptations, also posted support for Jeffries online.

[10] In August 2022, the film Beast was released, in which Jeffries played Norah Samuels.