The first station at the site, under the name Leamington was opened by the Great Western Railway (GWR) on its new main line between Birmingham, Oxford and London in 1852.

[1] This was not the first station in Leamington; the London and North Western Railway (LNWR) had reached the town eight years earlier in 1844, with a branch line from Coventry.

BR also removed passenger services from the Coventry branch at the same time, and closed all of the intermediate stations, leaving it open for freight trains only.

[10] Until the May 2023 timetable change,[11][12][13] a number of the Birmingham trains started from Kidderminster in the mornings and terminated there in the evenings, whilst a limited through service ran between Marylebone and Stratford-upon-Avon.

[15] West Midlands Railway operate an hourly local service to Nuneaton via Kenilworth, Coventry and Bedworth.

[20] The London and Birmingham Railway opened a motive power depot on the west side of the line at their Milverton station in 1844.

The Great Western Railway opened a motive power depot on the east side of the line south of Leamington Spa General Station in 1906.