The western entrance, found directly across from the archbishop's residence, is divided by fluted pilasters into three vertical sections corresponding to the three naves of the interior.

The cathedral has a Latin cross plan with three naves divided by pilasters and columns, and the main altar is placed at the eastern end of the church.

It has a longitudinal space that contains two Baroque chapels with paintings that is crossed by a long corridor consisting of ninety-two columns with capitals decorated with human figures.

It has a square shape and appears to be made up of five tapered levels, the last of which is surmounted by an octagonal majolica dome, on which there is an iron statue of Sant'Oronzo.

Engraved on plaques located over the mullioned windows are Latin inscriptions taken from the writings of Giovanni Lecce Camillo Palma.

At a height of 72 meters,[1] the bell tower offers views of the Adriatic Sea, and on clear days even the mountains of Albania are visible.