4X96, 4XWG, 4XX1, 5BV7393116816ENSG00000213398ENSMUSG00000035237P04180P16301NM_000229NM_008490NP_000220NP_032516Lecithin–cholesterol acyltransferase (LCAT, also called phosphatidylcholine–sterol O-acyltransferase) is an enzyme found in many animals, including humans.

This process sequesters cholesterol ester into the core of a lipoprotein particle, eventually making the newly synthesized HDL spherical and forcing the reaction to become unidirectional since the particles are removed from the surface.

The enzyme is bound to high-density lipoproteins (HDLs) (alpha-LCAT) and LDLs (beta-LCAT) in the blood plasma.

[5] LCAT deficiency can cause impaired vision due to cholesterol corneal opacities, anemia, and kidney damage.

Click on genes, proteins and metabolites below to link to respective articles.