In 2000, she formed her own record label LeSun Music and released her first album Soulsinger (2000), followed by Feeling Orange but Sometimes Blue.

In 2003, her first album was reissued as Soulsinger: The Revival on Tommy Boy Records.

[1] It featured the singles "Alright", "In the Morning", and "Joy"; all of which have peaked in the top-40 on Billboard's Adult R&B Songs chart.

In August 2020, Ledisi released The Wild Card on her own record label Listen Back Entertainment.

In March 2024, Ledisi released her eleventh album Good Life.