He is a research fellow at the Center for Philosophy and History of Science at Boston University and an instructor in ethics at Harvard Extension School.

[3] In 2000, McIntyre became a special assistant to the executive dean of the faculty and arts and sciences at Harvard University.

[7] McIntyre was an associate editor in the research department of the Federal Reserve Bank of Boston.

[8] Many of McIntyre's nonfiction books are concerned with the nature of scientific knowledge generation and validation.

[2][14] Publishers Weekly said that the book "articulates why the pursuit of scientific truths, even if inevitably flawed and subject to human error, matters.

New Statesman published his article, "Why Donald Trump and Vladimir Putin Lie... and Why They Are So Good At It" in January 2018.

[22] McIntyre's article "Flat Earthers and the Rise of Science Denial in America" was reprinted as the cover story of Newsweek on July 14, 2019.