He is a frequent collaborator with Apichatpong Weerasethakul and other Thai independent directors, but has also worked on commercial films, including the hit Thai horror film, Shutter.
Lee studied filmmaking in the United States.
He has been active since 1999, when he directed a short film, Miami Strips, Hollywood Dreams (Muang maya, krung tida).
He has worked with Apichatpong Weerasethakul on five films: Blissfully Yours, Tropical Malady, Syndromes and a Century, Uncle Boonmee Who Can Recall His Past Lives and Memoria.
In 2002, Lee founded his own post-production company, Houdini Studio.