During that year, she auditioned for play Agnes of God, a production directed by Yoon Kwang-jin and led by veteran actresses Park Jeong-ja and Son Sook.

Lee finally had the opportunity to portray her dream role and graced the stage as Agnes at the Jayu Small Theater in the Seoul Arts Center, starting from December 8.

Lee portrayed the character of Seon-jeong (Ophelia), alongside Jo Han-chul as Seok-dong (Hamlet), Min-ho as Romeo, and Bok-soon as Juliet.

The play explores a complex web of conflicting love in a contemporary setting that cleverly combines Hamlet and Romeo and Juliet.

[9][10] Lee collaborated with Director Seo Jae-hyung and Playwright Han Ah-reum from Theater Company Run to Death (극단-죽도록 달린다) in the premiere of play "Youth, 18 to 1."

She played the role of Natsuka, a Japanese woman deeply in love with Kim Kun-woo, a Korean man planning to assassinate the mayor of Tokyo.

[11] In late 2008, Lee collaborated once again with director Seo Jae-hyeong and playwright Han Ah-reum in the encore performance play "Hoya" (好夜).

[13][14] In April 2010, Lee Jin-hee reunited with director Seo Jae-hyeong and playwright Han Ah-reum to portray Jin-kyung in the play "Tournament."

48 Meters is a human rights film based on a true story about North Koreans risking their lives for freedom by crossing the Yalu River, which is called the distance between life and death.

In the film, Lee portrayed Ryu Hwa-young, a character who lost her parents while attempting to escape from North Korea as a child.

South Korean adaptation was written by Ji Yi-seon and translated by Kim Soo-bin and premiered in The 5th Best Plays Festival,[note 1] the Art One Theater in 2014.

In Kill Me Now, Lee Jin-hee plays the role of Twyla, who is the younger sister of Jake and the aunt of Joy, and takes care of the two.

During his performance in London in 2015, she received rave reviews from the British press for her honest and bold approach to difficult topics such as sex, disability, and death.

The play was based on a university performance titled "Hamlet —The Story of a Sad Clown," which was originally adapted and directed by Kim Dong-yeon in 2001.

[24] In 2018, Lee appeared in another MBC drama A Pledge to God in a supporting role as Na Hae-jim's mother, Ha Ji-mo.

The ensemble also included Son Ji-yoon, Seo Hyeon-cheol, Oh Yong, Jang Yi-joo, Yang So-min, Kim Do-bin, Ju Min-jin, Kwon Dong-ho, and Lee Hyung-hoon.

[30][31] The play involved "character juggling" as five actors onstage seamlessly transformed into various roles, including the centenarian protagonist Alan and the individuals he encounters.

[34] In episode 8 of the KBS drama Sell Your Haunted House (2021), she made a cameo appearance as the mother of Won-gwi Byul-i, a child ghost.

[35] Her appearance in episodes 2 and 9 of tvN drama series Hometown Cha-Cha-Cha as Hye-jin's mother, left lasting impression to viewers.

It tells the story of Gong Sang-du, a gangster who is preparing to surrender himself after committing a murder and meets his lover Hee-joo for the last time.

The play is based on the true story of two British mountain climbers, Joe Simpson and Simon Yates, and their struggle for survival.