[6] Mack went on to have various other jobs, and performed his first "open mic" slot in 1994, while studying at Brunel University, from where he graduated with a degree in Drama.

Five years later at the festival, he was nominated for the Perrier Award Main Prize for his sketch comedy show, Lee Mack's New Bits, with Catherine Tate and Dan Antopolski.

It features members of the audience taking part in silly games to get a spot in a sketch at the end of the show.

[14] In June 2012, Mack was one of the compères at Queen Elizabeth II's Diamond Jubilee Concert outside Buckingham Palace in London, introducing Cliff Richard, Ed Sheeran, and Madness.

In March 2013, Mack appeared on the panel on an episode of Let's Dance for Comic Relief with Arlene Phillips and Greg James.

[15] From 2014 to 2017, Mack presented Duck Quacks Don't Echo, a comedy-based panel show for Sky One, with various celebrity guests.

However, the show was suspended shortly after its debut in October 2020, after allegations emerged that one of the series' contestants, promoted through the channel's social media pages, bore facial tattoos resembling Nazi symbolism.

9 bus, but this turned out to be a deliberate hoax; the actual episode was "3 By 3", a supposed pilot quiz show hosted by Mack, that was introduced by the continuity announcer as a replacement for "Hold on Tight!".

Since September 2020, he has hosted a podcast on Buddhism and mindfulness with Neil Webster called I Can't Believe It's Not Buddha.

[26] In April 2001, Mack appeared at Up The Creek (in Greenwich)[27] and in 2003 he was regularly playing clubs around London - including Balham's Banana Cabaret, alongside Ian Cognito.

[29] In 2010, Mack took part in Channel 4's Comedy Gala, a benefit show held in aid of Great Ormond Street Children's Hospital, filmed live at the O2 Arena in London on 30 March.

Mack briefly appeared as the Narrator in the stage adaptation of BBC Radio 4 comedy series, Bleak Expectations.

[30] He made his stage acting debut in March 2017 in a West End revival of The Miser by Molière at the Garrick Theatre, starring Griff Rhys-Jones.

He also learned that his grandfather Joe was born in Southport, but was taken to Ireland as a baby and brought up by his grandparents in Ballina, County Mayo.

[34] In February 2009, Mack, along with other British entertainers, signed an open letter to The Times regarding the Baháʼí Faith leaders then on trial in Iran.

The first was for the most darts number twos in one minute, which stood until 19 November 2020 when Ricky Evans broke the record with a total of 25.

In September 2021, he scored for the first time,[46] in a year that he played for the World XI team, due to his Irish heritage from his great-grandmother.

[47] On 12 June 2022, Mack returned for the following game at the London Stadium, and scored the winning penalty for the World XI after a 2–2 draw in normal time.