He made his major league debut in relief against the New York Giants at the Polo Grounds on April 21, 1945, when professional baseball teams conducted spring training in the north.

His first major league win came in his first start, on May 14, 1945, as the Dodgers defeated the Pittsburgh Pirates 4–1 at Ebbets Field.

Even though he pitched 62.1 innings in 1945, Pfund tied for ninth among National League hurlers with 5 hit batsmen.

[2] In April 2012, Lee Pfund Stadium – outfitted with lights, new dugouts, a new backstop, and artificial turf – opened in Carol Stream, Illinois, where it is the home of the Wheaton baseball program.

[5] Pfund's son, Randy, was the head coach of the Los Angeles Lakers and later general manager of the Miami Heat.