After making her acting debut in the sitcom Nonstop 4, Lee has starred in the television series Pure 19 (2004), Princess Hours (2006), Dream High (2011), The King 2 Hearts (2012), and Wang's Family (2013).

[11][12] She, Danny Park and Kim Eui-sung starred in 992, a 13-minute film made by Wonsuk Chin using the iPhone 4S.

[13] The short, which premiered at the 2012 Macworld and was streamed on YouTube, is named after the New Balance running shoes favored by the late Apple CEO Steve Jobs.

[14][15] Lee stepped in to host the SBS talk show Healing Camp, Aren't You Happy for one episode, after the father of friend and agency mate Han Hye-jin died in November 2012.

[22][23][24][25][26] A devout Roman Catholic who attends Mass every Sunday, Lee said in an interview in 2010: "Faith is a joyful thing for me, and it's a normal part of everyday life.