As with the original film, the series features the characters Donald Duck, José Carioca, and Panchito Pistoles.

When Donald Duck inherits a cabana from his great-grandfather Clinton Coot in the New Quackmore Institute alongside Brazilian parrot José Carioca and Mexican rooster Panchito Gonzalez, they discover a magical book that when opened releases a goddess named Xandra.

The goddess explains that Donald, José, and Panchito are the descendants of a trio of adventurers known as the Three Caballeros, who long ago travelled to stop the evil sorcerer Lord Felldrake from taking over the world and ultimately sealed him in a magical staff.

Meanwhile, the staff containing Felldrake is discovered by his descendant Baron Von Sheldgoose, the corrupt President of the New Quackmore Institute.

The show's main voice cast includes: The series was first released on the DisneyLife app in the Philippines on June 9, 2018,[5] and premiered on Disney Channel in Southeast Asia on January 1, 2019.