Founded in AD 39 by the emperor Caligula for use in his campaigns in Germania, the XXII Primigenia spent much of their time in Mogontiacum (modern Mainz) up to the end of the 3rd century.
During the Batavian rebellion, XXII Primigenia, commanded by Gaius Dillius Vocula, was the only Germanic legion that survived rebel attacks and which stayed in its camp, defending Moguntiacum.
Around 90 units of the XXII were garrisoned in or around the area of modern-day Butzbach, as part of the Limes Germanicus (a series of forts along the Roman frontier of Germania Superior.
The Rhine settlement was their main camp, but vexillationes of the legion participated in the building of the Antonine Wall in Scotland (2nd century) and in the campaigns against the Sassanid Empire (around 235).
[dubious – discuss] The following year, the XXII Legion rebelled against Postumus, and proclaimed its commander Laelianus Emperor of the Gallic Empire.