The railway line between Hanover and Lehrte via Peine was built in 1843 and extended in the following years to Brunswick (Braunschweig).

Branch lines were subsequently built from Lehrte to Celle (1845) and to Hildesheim (1846).

In 1844, an entrance building was built in the neoclassical style to a design by Eduard Ferdinand Schwarz.

As a result, the level crossings that had been common in Lehrte were removed in the centre of the town.

By the summer of 2008, the junction in Lehrte was rebuilt again to provide a grade-separated connection for freight trains from the Hanover freight bypass to the east and to give a grade-separated route from Celle to Hildesheim and Brunswick; this involved the raising of the tracks of the high-speed rail line.