Throughout his acting career, McCloskey appeared in numerous television series and movies, including the popular American soap opera Dallas and a leading role in the Dario Argento-helmed supernatural horror film Inferno.

As a painter, McCloskey has produced a number of works focused on occult, alchemical, and esoteric themes, including his own Tarot deck and The Hieroglyph of the Human Soul, a mixed-media art installation painted on the walls of his home library.

His art work has been featured in popular music, including Flying Lotus’ 2010 release Cosmogramma[1][2][3] and The Rolling Stones’ A Bigger Bang Tour in the 2000s.

[citation needed] While working on Dallas, McCloskey found himself dissatisfied with mainstream success and began exploring painting and writing as a means of creative fulfillment.

[5] His work as a visual artist explores religion, mythology, philosophy, esotericism and human consciousness, and reflects his deep study of Hermeticism, Alchemy and Kabbalah.

McCloskey's most notable accomplishment as a visual artist is generally considered to be The Hieroglyph of the Human Soul, an installation work painted on the walls of his personal library.

[7][8][9] The Hieroglyph is a mixed-media acrylic mural that depicts the archetypal story of creation and evolution of the human soul, through which McCloskey gives guided tours to reveal its rich symbolism.

One critic wrote, “Stepping into The Hieroglyph of the Human Soul, the visitor is transported into a liminal space of consciousness that is at once a library and a temple, a stage and a studio, a cave painting and a cathedral.

[1][2][3] Imagery from McCloskey’s Grimoire (itself an unused prop from the E. Elias Merhige horror film Shadow of the Vampire) was prominently featured on The Rolling Stones' A Bigger Bang Tour in the 2000s.

"[14] Upon its publication, American occult historian Mitch Horowitz likened Tarot ReVisioned to Manly P. Hall's classic esoteric tome The Secret Teaching of All Ages.

[14] McCloskey has also published Codex Tor I & II (which served as the cover for Flying Lotus' Cosmogramma), Adam Reborn & Eve Restored, and In the Splendor.