It stars Gelman, Judy Greer, Michael Cera, Shiri Appleby, Fred Melamed, Rhea Perlman, David Paymer, Gillian Jacobs, Jon Daly, Martin Starr, Megan Mullally, Jeff Garlin, Elizabeth De Razzo, Marla Gibbs and Nia Long.

Isaac is a middle-aged actor who lives with his girlfriend, Ramona, who is blind and works for a pharmaceutical company that requires her to travel frequently.

Isaac leads an acting workshop where he routinely lavishes praise on Alex, his star pupil who is also a working actor, while either denigrating or ignoring Tracy, another one of his students.

He is secretly jealous of Alex as his own acting career has devolved into commercial and modeling work for pharmaceutical products.

In August 2016, it was announced that Brett Gelman, Judy Greer, Michael Cera, Nia Long, Fred Melamed, Shiri Appleby, Rhea Perlman, David Paymer, Gillian Jacobs, Megan Mullally, Martin Starr, Jeff Garlin and Marla Gibbs would star in the film, with Janicza Bravo directing and executive producing the film from a screenplay she wrote alongside Gelman.

The site's critical consensus says "Lemon succeeds in its aim as a tart satire, but audiences may find this foray into abrasiveness too sour to swallow.

[12] Todd McCarthy of The Hollywood Reporter praised the film, and wrote: "Lemon represents a feature debut of unusual assurance and control with a style all its own.