Lena Luthor first appeared in Superman's Girl Friend, Lois Lane #23 and was created by Jerry Siegel and Kurt Schaffenberger.

As a result, Lena never knew she had an older brother, as Lex Luthor himself (with occasional help from Supergirl and Superman) worked to keep her from learning the truth.

After the initial shock, there were signs of reconciliation after Luthor discovered he had unwittingly aided another criminal's conspiracy against Lena, and he was deeply apologetic.

[4] In Final Crisis: Legion of 3 Worlds #3, Legionnaires Polar Boy, Wildfire, and Dawnstar travel to Smallville during the 20th century, back to when Superman was still a suburban legend.

[6] In the revived Adventure Comics, Lex made certain to cover up his Smallville history, and that included disavowing a connection to his sister.

Both were shocked to find Lex Luthor on Lori's doorstep, intent on taking control of Superboy again and claiming he can cure Lena's condition.

He was eventually able to treat her paralysis, but delayed the treatment as it involved technology he did not invent himself, leaving Lena enraged that he expected her to be forever under his shadow.

A desperate Lex tried to use Doctor Omen's Super-Man technology to cure Lena only for it to make her more paralyzed and give her a higher intellect as well as developing a psychic link to her Mother Box.

At the end of the crossover, Brainiac 13 and Imperiex are both destroyed, and Lena is regressed to infanthood and returned to her father by Superman, who tells Luthor that he now has a second chance to try to be a man instead of a god.

Throughout the series, Lena secretly works with Lex to help him seek revenge against Superman until she learns Supergirl's identity.

Lena Luthor appears in DC Super Hero Girls: Teen Power, voiced again by Cassandra Lee Morris.