Over the course of the series, Fitz suffers multiple traumas and becomes aware of a darker and more ruthless side to his character.

They are rescued by Nick Fury, but Fitz sustains damage to his temporal lobe as a result of oxygen deprivation and is left comatose.

[6] In season two, Fitz initially struggles with technology and speech as a result of Ward's actions,[7] but over time becomes a full member of the team again.

[8] Near the end of the season Fitz arranges for a date with Simmons when the Kree weapon called "Monolith", which is in S.H.I.E.L.D.

ally Holden Radcliffe has created the android Aida, and agrees to help perfect her, while initially keeping this from Simmons.

[16][1] After he creates for Aida a machine to become a real person, Fitz is forced out of the Framework,[17] and is traumatized from his behavior there.

Enoch, a Chronicom, helps him escape to a secret bunker where Fitz learns that he was left behind so he could save the team.

[23] Due to multiple stressful factors, Fitz experiences a psychic split which enables his "Doctor" personality from the Framework to temporarily resurface.

[24] During the final battle against a gravitonium-enhanced Glenn Talbot, Fitz is buried under a rubble and later found fatally injured when dug out by fellow agents Melinda May and Mack where he succumbs to his wounds.

[28] For Fitz's safety, Simmons surrenders herself to Atarah, Enoch's former superior, so that the two of them can come up with a time-traveling method for the Chronicoms to use.

[29] Atarah traps Fitz and Simmons inside their own minds, forcing them to work together in figuring out time travel logic.

The trio then teleport away,[30] but end up again on Kitson, where Fitz and Simmons are saved from execution by mercenary Izel, who helps them on their return to Earth while Enoch bids them farewell.

[33] In season seven, Fitz stays behind while the rest of the team is transported to the past to stop the Chronicoms from invading the Earth.

[34] Fitz then devises yet another plan to bring his friend and the enemy Chronicoms back to the original timeline, which he achieves successfully.

[36] Following injuries Fitz receives at the end of the first season, the series began to deal with brain trauma, as De Caestecker explained "From the get-go, before I even knew about it, the writers had the idea, and they did a lot of research in it with doctors.

[46] Fitz has a lot of interaction with Simmons in the series, with De Caestecker explaining "My character, he's Engineering, so he's on the computer and tech side of everything.

"[47] Regarding the changing dynamic over time between Fitz and Simmons, De Caestecker said "I suppose what's happened from the start of season two up to midseason is, they've become a lot stronger as individuals, I think.

"[37] Fitz also develops a close friendship with Alphonso "Mack" Mackenzie, beginning when the latter joins the cast in season two.

[52] He joins Phil Coulson's team to regain the Uru Sword, an ancient weapon that belonged to Heimdall.

With Scarlet Witch's help, the team traveled to Antarctica to find the source and managed to defeat the people who were making the bullets.

[58] Fitz, voiced by De Caestecker, appeared in "Lizards" a fourth season episode of the animated TV series Ultimate Spider-Man.