In 1975, Milo was accepted into the Juilliard School to study timpani and percussion with Saul Goodman and Elden C. “Buster” Bailey.
At the same time and also at Juilliard, he began studying composition and contemporary music analysis with Stanley Wolfe, who encouraged him while writing his first pieces.
At Juilliard, he worked with conductors such as Sixten Ehrling, Leonard Bernstein, Georg Solti, Herbert von Karajan, Pierre Boulez and Myung-Whun Chung.
Between 1981 and 1984, he worked with conductors like Mendi Rodan, Jean-Pierre Rampal, Paul Tortelier, Zubin Mehta, Isaac Stern and Karsten Andersen.
A year later, he was accepted to the composer's workshop at the Aspen Music Festival where he studied with Luciano Berio, Jacob Druckman, Earle Brown and Morton Subotnick.
In 1986, after two years of study with Leonard Stein, he was commissioned to write a piece for the LA Philharmonic new music ensemble, by the composer in residence John Harbison.
That year, he studied privately with Gilbert Amy and attended master classes at the American School in Fontainebleau with Tristan Murail and Betsy Jolas.
In the mid-nineties, he started to work on computer assisted composition, stying studied electronic music at the ateliers UPIC with Curtis Roads and Gérard Pape.
Following, were numerous collaborations such as Levy's Pompidou Art Center installation, Love Counts and Osmosis for the SWAROVSKI CRYSTAL PALACE in Milan.
Leon Milo composed Mexico for the Trio d'Argent in 2002 and soon after began developing interactive programming for live performance.
He devised many interactive sequences in collaboration with Francois Daudin Clavaud for the Trio d'argent and dancer on tightrope for performances for a contemporary music evening called El Horizonte.
[6] 2005, Milo was commissioned by the Festival Ile de France and the Trio d'Argent to write a piece for 3 percussionists, 3 flutists and live electronics.
In honor of French composer Olivier Messiaen's 100th birthday in 2008, Susanne Kessel conceived a program presented by "PIANOWAVES" at the International Beethovenfest.
In September 2009, Milo and Francois Daudin Clavaud played their interactive performance entitled “Sound Gardens” numerous times in Mexico.
Other contributing composers were Alex Shapiro, Alvin Lucier, Michael Denhoff, Ulrike Haage, Christoph Israel, Moritz Eggert, Ivan Sokolov, Mike Lang.
2012, Milo wrote the original music[10] for a ten-part fiction based on the novel Pedro Páramo produced by Radio France.