He is known for hosting the podcasts Slow Burn and Fiasco,[2] and his book The Next Next Level: A Story of Rap, Friendship, and Almost Giving Up.

[6] Neyfakh is best known for creating and hosting Slate's podcast Slow Burn, which has covered American political scandals.

[5] Neyfakh also wrote a book titled The Next Next Level: A Story of Rap, Friendship, and Almost Giving Up, about Juiceboxxx, a rapper from Wisconsin.

[14] In February 2019, it was announced that Epix would release a six-part docu-series inspired by Slow Burn with Neyfakh as host.

When asked about how Americans can actively and effectively engage in the topic of race, Neyfakh said: I think there should be more recognition on the part of white people like me that believing in equality usually means giving something up.

[20] In 2023, Neyfakh and radio deejay and cultural commentator Jay Smooth released the "Think Twice" podcast covering the legacy of singer and performer Michael Jackson.