[2] He was a grand-nephew of Pope Sixtus IV and a nephew of Cardinal Girolamo Basso della Rovere.
[2] He received the red hat and the titular church of Santi Apostoli, Rome on 17 December 1505.
[2] He accompanied the pope on his expeditions against the House of Bentivoglio in Bologna and the Baglioni family of Perugia.
[2] In this capacity, he collaborated with Michelangelo on the Tomb of Pope Julius II in San Pietro in Vincoli.
[2] Cardinal della Rovere opted for San Pietro in Vincoli as his titulus on 9 March 1517.