[6] That offseason, the Universidad Anáhuac Cancún faced financial problems which caused uncertainty about the Leones' future in ONEFA.

[11] Anáhuac Cancún qualified for the expanded playoffs, but they were eliminated in the quarterfinals after a 48–14 defeat to Grupo Verde team Pumas CU.

[15] In 2018, the Leones finished the regular season undefeated with a 6–0 record,[16][17] However, they were eliminated in the Grupo Blanco semifinals again, this time after a 35–33 defeat to the Lobos UAdeC.

[19] The Leones promoted their offensive coordinator, Jorge Jiménez Aréchiga, to replace Martos as the team's head coach in May 2019.

[21] In their first year under coach Jiménez Aréchiga, the Leones went 7–0 in the regular season and led ONEFA in scoring with 41.9 points per game.

[24] Despite an early injury to star running back Axel Montini in the championship game, quarterback José Rovirosa scored three total touchdowns to lead the team to a 29–21 victory, completing their perfect season and capturing the second conference title in program history.

[28] For 2021, it was announced that Anáhuac Cancún would be moved to the newly created Conferencia Nacional Centro-Sur and play a shortened four-game season.

[32] They went on to defeat the Leones Anáhuac Querétaro and the Red Wolves ASUCQ to finish the season with a 3–1 record, though no conference champion was crowned.